Sunday, April 10, 2011

Tony Oursler

http://www.tonyoursler.com/individual_work_slideshow.php?navItem=work&workId=18&startDateStr=Feb.%2025,%202006&subSection=Installations&allTextFlg=true&title=Thought%20Forms

under skin

http://www.lozano-hemmer.com/under_scan.php

Learned helplessness

Learned helplessness, as a technical term in animal psychology and related human psychology, means a condition of a human person or an animal in which it has learned to behave helplessly, even when the opportunity is restored for it to help itself by avoiding an unpleasant or harmful circumstance to which it has been subjected. Learned helplessness theory is the view that clinical depression and related mental illnesses may result from a perceived absence of control over the outcome of a situation.[1]

Seligman and Maier
The American psychologist Martin Seligman's foundational experiments and theory of learned helplessness began at University of Pennsylvania in 1967, as an extension of his interest in depression. Quite by accident, Seligman and colleagues discovered that the conditioning of dogs led to outcomes that opposed the predictions of B.F. Skinner's behaviorism, then a leading psychological theory.[2][3]
In part one of Seligman and Steve Maier's experiment, three groups of dogs were placed in harnesses. Group One dogs were simply put in the harnesses for a period of time and later released. Groups Two and Three consisted of "yoked pairs." A dog in Group 2 would be intentionally subjected to pain by being given electric shocks, which the dog could end by pressing a lever. A Group 3 dog was wired in parallel with a Group 2 dog, receiving shocks of identical intensity and duration, but his lever didn't stop the electric shocks. To a dog in Group 3, it seemed that the shock ended at random, because it was his paired dog in Group 2 that was causing it to stop. For Group 3 dogs, the shock was apparently "inescapable." Group 1 and Group 2 dogs quickly recovered from the experience, but Group 3 dogs learned to be helpless, and exhibited symptoms similar to chronic clinical depression.
In part two of the Seligman and Maier experiment, these three groups of dogs were tested in a shuttle-box apparatus, in which the dogs could escape electric shocks by jumping over a low partition. For the most part, the Group 3 dogs, who had previously "learned" that nothing they did had any effect on the shocks, simply lay down passively and whined. Even though they could have easily escaped the shocks, the dogs didn't try.
In a second experiment later that year, Overmier and Seligman ruled out the possibility that the Group 3 dogs learned some behavior in part one of the experiment, while they were struggling in the harnesses against the "inescapable shocks," that somehow interfered with what would have been their normal, successful behavior of escaping from the shocks in part two. The Group 3 dogs were immobilized with a paralyzing drug (Curare), and underwent a procedure similar to that in part one of the Seligman and Maier experiment. A similar part two in the shuttle-box was also undertaken in this experiment, and the Group 3 dogs exhibited the same "helpless" response.
However, not all of the dogs in Seligman's experiments became helpless. Of the roughly 150 dogs in experiments in the latter half of the 1960s, about one-third did not become helpless, but instead managed to find a way out of the unpleasant situation despite their past experience with it. The corresponding characteristic in humans has been found to correlate highly with optimism: an explanatory style that views the situation as other than personal, pervasive, or permanent. This distinction between people who adapt and those who break down under long-term psychological pressure was also studied in the 1950s in the context of brainwashing.
[edit]Later experiments
Other experiments were performed with different animals with similar results. In all cases, the strongest predictor of a depressive response was lack of control over the aversive stimulus. One such later experiment, presented by Watson & Ramey (1969), consisted of two groups of human babies. One group was placed into a crib with a sensory pillow, designed so that the movement of the baby’s head could control the rotation of a mobile. The other group had no control over the movement of the mobile and could only enjoy looking at it. Later, both groups of babies were tested in cribs that allowed the babies to control the mobile. Although all the babies now had the power to control the mobile, only the group that had already learned about the sensory pillow attempted to use it.[4]
A similar experiment was done with people who performed mental tasks in the presence of distracting noise. People who could use a switch to turn off the noise had improved performance, even though they rarely bothered to do so. Simply being aware of this option was enough to substantially counteract its distracting effect.[5]
[edit]The attributional reformulation

Later research discovered that the original theory of learned helplessness failed to account for people's varying reactions to situations that can cause learned helplessness.[6] Learned helplessness sometimes remains specific to one situation,[7] but at other times generalizes across situations.[5]
An individual's attributional style or explanatory style was the key to understanding why people responded differently to adverse events.[8] Although a group of people may experience the same or similar negative events, how each person privately interprets or explains the event will affect the likelihood of acquiring learned helplessness and subsequent depression.[9]
People with pessimistic explanatory style—which sees negative events as permanent ("it will never change"), personal ("it's my fault"), and pervasive ("I can't do anything correctly")—are most likely to suffer from learned helplessness and depression.[10] Cognitive behavioral therapy, heavily endorsed by Seligman, can often help people to learn more realistic explanatory styles, and can help ease depression.
Bernard Weiner's attribution theory (1979, 1985, 1986) concerns the way that people attribute a cause or explanation to an unpleasant event. Attribution theory includes the dimensions of globality/specificity, stability/instability, and internality/externality.[11] A global attribution occurs when the individual believes that the cause of negative events is consistent across different contexts. A specific attribution occurs when the individual believes that the cause of a negative event is unique to a particular situation. A stable attribution occurs when the individual believes the cause to be consistent across time. Unstable attribution occurs when the individual thinks that the cause is specific to one point in time. An external attribution assigns causality to situational or external factors, while an internal attribution assigns causality to factors within the person.[9]
[edit]Differences between humans and other animals

There are several aspects of human helplessness that have no counterpart among other animals. One of the most intriguing aspects is "vicarious learning (or modelling)": that people can learn to be helpless through observing another person encountering uncontrollable events.[12] However, studies with animals have shown that many species can learn through observation.[13] Thus, this difference may not exist between humans and nonhumans.
Apart from the shared depression symptoms between human and other animals such as passivity, introjected hostility, weight loss, appetite loss, social and sexual deficits, some of the diagnostic symptoms of learned helplessness—including depressed mood, feelings of worthlessness, and suicidal ideation—can be found and observed in human beings but not necessarily in animals.[10]
[edit]Health implications

Whatever their origins, people who suffer uncontrollable events reliably see disruption of emotions, aggressions, physiology, and problem-solving tasks.[14][15] These helpless experiences can associate with passivity, uncontrollability and poor cognition in people, ultimately threatening their physical and mental well-being.
[edit]Physical health
Learned helplessness can contribute to poor health when people neglect diet, exercise, and medical treatment, falsely believing they have no power to change. The more people perceive events as uncontrollable and unpredictable, the more stress they experience, and the less hope they feel about making changes in their lives.[16][17]
Young adults and middle-aged parents with a pessimistic explanatory style are often more likely to suffer from depression.[18] People with a pessimistic explanatory style tend to be poor at problem-solving and cognitive restructuring, and also tend to demonstrate poor job satisfaction and interpersonal relationships in the workplace.[16][19] Those with a pessimistic explanatory style also tend to have weakened immune systems, and not only have increased vulnerability to minor ailments (e.g. cold, fever) and major illness (e.g. heart attack, cancers), but also have a less effective recovery from health problems.[20]
[edit]Psychological health
Learned helplessness can also be a motivational problem. Individuals who have failed at tasks in the past conclude erroneously that they are incapable of improving their performance.[21] This might set children behind in academic subjects and dampen their social skills.
Children with learned helplessness typically fail academic subjects, and are less intrinsically motivated than others. They may use learned helplessness as an excuse or a shield to provide self-justification for school failure. Additionally, describing someone as having learned to be helpless can serve as a reason to avoid blaming him or her for the inconveniences experienced. In turn, the student will give up trying to gain respect or advancement through academic performance.[22]
[edit]Social impact
Child abuse by neglect can be a manifestation of learned helplessness: when parents believe they are incapable of stopping an infant's crying, they may simply give up trying to do anything for the child.[23]
Another example of learned helplessness in social settings involves loneliness and shyness. Those who are extremely shy, passive, anxious and depressed may learn helplessness to offer stable explanations for unpleasant social experiences. However, Gotlib and Beatty (1985) found that people who cite helplessness in social settings may be viewed poorly by others, resulting in a situation that reinforces the problematic thinking. A third example is aging, with the elderly learning to be helpless and concluding that they have no control over losing their friends and family members, losing their jobs and incomes, getting old, weak and so on.[24]
Social problems resulting from learned helplessness seem unavoidable; however, the effect goes away with the passage of time.[25] Nonetheless, learned helplessness can be minimized by "immunization" and potentially reversed by therapy. People can be immunized against the perception that events are uncontrollable by increasing their awareness of previous positive experiences.[26] Therapy can instruct people in the fact of contingency[27] and bolster people's self esteem.[28]
[edit]Extensions

The American sociologist Harrison White has suggested in his book Identity and Control that the notion of learned helplessness can be extended beyond psychology into the realm of social action. When a culture or political identity fails to achieve desired goals, perceptions of collective ability suffer.
According to author Jane Mayer,[29] Seligman gave a talk at the Navy SERE school in San Diego in 2002, which he said was a three-hour talk on helping U.S. soldiers to resist torture, based on his understanding of learned helplessness.

THE STAGES OF GRIEF

A Normal Life Process

At some point in our lives, each of us faces the loss of someone or something dear to us. The grief that follows such a loss can seem unbearable, but grief is actually a healing process. Grief is the emotional suffering we feel after a loss of some kind. The death of a loved one, loss of a limb, even intense disappointment can cause grief. Dr. Elisabeth Kubler-Ross has named five stages of grief people go through following a serious loss. Sometimes people get stuck in one of the first four stages. Their lives can be painful until they move to the fifth stage - acceptance.

Five Stages Of Grief

Denial and Isolation.
At first, we tend to deny the loss has taken place, and may withdraw from our usual social contacts. This stage may last a few moments, or longer.
Anger.
The grieving person may then be furious at the person who inflicted the hurt (even if she's dead), or at the world, for letting it happen. He may be angry with himself for letting the event take place, even if, realistically, nothing could have stopped it.
Bargaining.
Now the grieving person may make bargains with God, asking, "If I do this, will you take away the loss?"
Depression.
The person feels numb, although anger and sadness may remain underneath.
Acceptance.
This is when the anger, sadness and mourning have tapered off. The person simply accepts the reality of the loss.
Grief And Stress

During grief, it is common to have many conflicting feelings. Sorrow, anger, loneliness, sadness, shame, anxiety, and guilt often accompany serious losses. Having so many strong feelings can be very stressful.

Yet denying the feelings, and failing to work through the five stages of grief, is harder on the body and mind than going through them. When people suggest "looking on the bright side," or other ways of cutting off difficult feelings, the grieving person may feel pressured to hide or deny these emotions. Then it will take longer for healing to take place.

Recovering From Grief

Grieving and its stresses pass more quickly, with good self-care habits. It helps to have a close circle of family or friends. It also helps to eat a balanced diet, drink enough non-alcoholic fluids, get exercise and rest.

Most people are unprepared for grief, since so often, tragedy strikes suddenly, without warning. If good self-care habits are always practiced, it helps the person to deal with the pain and shock of loss until acceptance is reached.

Wednesday, April 6, 2011

Food Repelling

Human's organ



The stage about death

* Moment of Death:
1} The heart stops
2} The skin gets tight and grey in color
3} All the muscles relax
4} The bladder and bowels empty
. . . .4a - Men will get an erection. No, I don't know when, exactly. I really didn't feel like calling up the local mortuary and asking this. And there's people on my mailing list I could have asked, I bet, but it's kind of weird popping up and asking that. No pun intended. I'm not sure my parents know what erections are, so I can't ask them. I did read that this was one of the reasons hangings were so well attended by women, back in the old.days. Big Laffs, seeing the Hung, hung.
5} The body's temperature will typically drop 1.5 degrees F. per hour unless outside environment is a factor. The liver is the organ that stays warmest the longest, and this temperature is used to establish time of death if the body is found within that time frame.

* After 30 minutes:
6} The skin gets purple and waxy
7} The lips, finger- and toe nails fade to a pale color or turn white as the blood leaves.
8} Blood pools at the lowest parts of the body leaving a dark purple-black stain called lividity
9} The hands and feet turn blue
10} The eyes start to sink into the skull

* After 4 hours:
11} Rigor mortis starts to set in
12} The purpling of the skin and pooling of blood continue
13} Rigor Mortis begins to tighten the muscles for about another 24 hours, then will reverse and the body will return to a limp state.

* After 12 hours:
14} The body is in full rigor mortis.

* After 24 hours:
15} The body is now the temperature of the surrounding environment
16} In males, the semen dies
17} The head and neck are now a greenish-blue color
18} The greenish-blue color continues to spread to the rest of the body
19} There is the strong smell of rotting meat
20} The face of the person is essentially no longer recognizable

* After 3 days:
21} The gases in the body tissues form large blisters on the skin
22} The whole body begins to bloat and swell grotesquely. This process is speeded up if victim is in a hot environment, or in water
23} Fluids leak from the mouth, nose, eyes, ears and rectum and urinary opening

* After 3 weeks:
24} The skin, hair, and nails are so loose they can be easily pulled off the corpse
25} The skin cracks and bursts open in many places because of the pressure of Internal gases and the breakdown of the skin itself
26} Decomposition will continue until body is nothing but skeletal remains, which can take as little as a month in hot climates and two months in cold climates. The teeth are often the only thing left, years and centuries later, because tooth enamel is the strongest substance in the body. The jawbone is the densest, so that usually will also remain. So don't forget - brush regularly and floss only if you're really bored.

Sunday, March 20, 2011

Turning cancer cells into a work of art

Stefanie Reichelt, a scientist at the Cambridge Research Institute, believes that cancer cells are beautiful. In fact, when viewed under a microscope, she thinks that all parts of the human body - from chromosomes to sperm - are visually arresting.
As head of the microscopy laboratory, the images that her team produce are crucial to developing new treatments. The pictures focus on cell division, a process that spirals out of control in cancer, leading to the formation of tumours.
But Reichelt also has an artistic streak. She was so taken with the beauty of the cells, artificially stained with a rainbow of vibrant colours to highlight certain features, that she started to make a collection of etchings based on the microscopic vistas.
Her work is on display at the institute, although she admits that the pictures are not always greeted with enthusiasm. “People sometimes say ‘Oh no, pictures of cancer cells, that's horrible.' But then they see that they are actually very beautiful.”
The exhibition is free and runs until September 30, 10am-5pm seven days a week, at ArtCell, the art gallery at Cancer Research UK's Cambridge Research Institute; tel: 01223 404180,http://stefaniereichelt-photographyandprints.org
SPIN CYCLE
This etching is based on the nucleus of a cell. Acting as the cell's headquarters, it contains all the precious genetic material, held in a long spiralled string. The red dot is the nucleolus, a sub-section of the nucleus.
This cell is in the so-called quiet phase, the time between busy periods of division. Scientists once thought that our cells were inactive at this point, before realising that they were in fact performing many vital functions, invisible even through a microscope.
The image, right, is a real cell. The nucleus is the black area, with the surrounding material, termed cytoskeleton, stained green.
X-TREME CLOSE UP
This is an etching of a real chromosome, based on what Reichelt observes through her microscope. Chromosomes are organised structures of DNA, grouped into genes. The bands, painted with fluorescent dyes, represent the positions of certain genes. In disease diagnosis and research, “painting chromosomes” can help scientists to detect abnormal genes, which may indicate cancer.
The etchings are produced by scoring the image on to a metal plate, covering it with ink and printing on to paper. Each colour requires a separate plate, so the image is built up layer by layer.
LIFE RACE
Fertilisation is the moment when a sperm and egg join together, and the genes from the mother and father combine to form a new life. This etching is based on what scientists see when observing the process through a microscope. Although Reichelt would not normally observe this process, as her work is based on cancer cells, many researchers spend hours watching it. The observations can provide clues as to why a couple has difficulty conceiving.
THE BIG SPLIT
This is an etching of what Reichelt believes is the most dramatic process that our cells perform: division, when one cell becomes two. It keeps us alive, and healthy, but can be deadly if it goes wrong. When cells divide, genetic material is duplicated before splitting into two identical portions. Here, the chromosomes have duplicated, making a butterfly shape. The “wings” are then pulled apart, with one side going to each new cell. In cancer, the mechanisms that keep the genetic material intact often malfunction.
ONE BECOMES TWO
In this etching, which Reichelt based on real scientific images, one cell is dividing to make two. Scientists are interested in this process because errors can result in cancer.
The V-shaped structures are chromosomes, which hold a cell's genetic material. Special strings pull them to opposite ends, ready to make two new cells. A real image (right) shows the strings highlighted in green.
SCIENTISTS TURN THEIR HAND TO TEXTILES
When the scientist Sir Tim Hunt won the Nobel Prize for Medicine in 2001, he never imagined that one day he would be helping to make wallpaper. Or that four of his fellow Nobel prizewinners would be making dresses, rugs and fabrics.
They are not the latest victims of the credit crunch, but are teaming up with research fellows from Central Saint Martin's College of Art and Design to produce textiles based on their scientific discoveries. The results of the project, funded by the college and the Medical Research Council, go on show in London this month. Hunt, who discovered a crucial process in cell biology, worked with the designer Rachel Kelly. His Nobel-winning experiments used sea urchin eggs, which inspired Kelly's wallpaper design (left). Meanwhile, Sir Peter Mansfield, who developed the scanning technique magnetic resonance imaging (MRI), worked with the dress designer Shelley Fox, who made clothes, based on scans, to represent our changing body shapes.

Cancer Cells Paintings

Artist: Angela Canada Hopkins
http://www.canadahopkins.com/large-single-view/Cancer%20Cells/226195-1-7424/Painting.html

Monday, March 14, 2011

Syndyn [MaxMSP, Game, Environment]

Created by André Rangel and Anne-Kathrin Siegel, Syndyn is a physical game but also a visual environment where the players control all the audiovisual events that occur in the space/time of the game. They perform a live show and simultaneously produce a database of light drawn images.
The space where the event takes place is colored with light which is controlled by players movements. Their rackets and arms are decorated with electro luminescent wire and the shuttlecock (speeder) with a bright LED, providing vivid dynamic scenic effects.
In the beginning of each game, users choose on an iPod ™ touch device a soundscape associated with visuals and colors for the ambience lighting system. Syndyn rackets are equipped with sensors that detect each hit of the speeder. A radio transmitter system broadcasts the sensors data to the central processing unit (computer). The hits on the rackets are accompanied by synchronous real-time synthesized sounds, by an instant change in the ambience light color according to the previous players choices and by real time generated visuals.
In addition to this real-time audiovisual response, players can also take a visual memory of their game. A long exposure photographic camera covers the playing area. This camera registers the traces that represent the trajectories and movements of the lighting speeder, the lighting racquets and the lighting arms. The resulting drawings of light, can be automatically printed with photographic quality paper and offer to players. These images are automatically stored in a database that feeds a web photo gallery.
Literally the possibility of drawing with this game, gives Syndyn its original and innovative character: being simultaneously an artistic, sports, and entertainment event that merges aesthetics, physical activity, technology and entertainment.

Tuesday, March 8, 2011

Food Pyramid

From MIT

Organic Food Game

http://www.organicfoodbarkids.com/play_the_games

About Cancer

  1. What is cancer?
    Cancer is a group of many related diseases that begin in cells, the body's basic building blocks. To understand cancer, it is helpful to know what happens when normal cells become cancerous.
    The body is made up of many types of cells. Normally, cells grow and divide to produce more cells as they are needed to keep the body healthy. Sometimes, this orderly process goes wrong. New cells form when the body does not need them, and old cells do not die when they should. The extra cells form a mass of tissue called a growth or tumor. Not all tumors are cancerous; tumors can be benign or malignant.
    Benign tumors are not cancer. They can often be removed and, in most cases, they do not come back. Cells in benign tumors do not spread to other parts of the body. Most important, benign tumors are rarely a threat to life.
    Malignant tumors are cancer. Cells in malignant tumors are abnormal and divide without control or order. Cancer cells invade and destroy the tissue around them. Cancer cells can also break away from a malignant tumor and enter the bloodstream or lymphatic system.
    Blood vessels include a network of arteries, capillaries, and veins through which the bloodcirculates in the body. The lymphatic system carries lymph and white blood cells through lymphatic vessels (thin tubes) to all the tissues of the body. By moving through the bloodstream or lymphatic system, cancer can spread from the primary (original) cancer site to form new tumors in otherorgans. The spread of cancer is called metastasis.
  2. What causes cancer?
    Scientists have learned that cancer is caused by changes in genes that normally control the growth and death of cells. Certain lifestyle and environmental factors can change some normal genes into genes that allow the growth of cancer. Many gene changes that lead to cancer are the result of tobacco use, diet, exposure to ultraviolet (UV) radiation from the sun, or exposure tocarcinogens (cancer-causing substances) in the workplace or in the environment. Some genealterations are inherited (from one or both parents). However, having an inherited gene alteration does not always mean that the person will develop cancer; it only means that the chance of getting cancer is increased. Scientists continue to examine the factors that may increase or decrease a person's chance of developing cancer.
    Although being infected with certain viruses, such as the human papillomavirus (HPV), hepatitis Band C (HepB and HepC), and human immunodeficiency virus (HIV), increases the risk of some types of cancer, cancer itself is not contagious. A person cannot catch cancer from someone who has this disease. Scientists also know that an injury or bruise does not cause cancer.
  3. Can cancer be prevented?
    Although there is no guaranteed way to prevent cancer, people can reduce their risk (chance) of developing cancer by:
    • not using tobacco products
    • choosing foods with less fat and eating more vegetables, fruits, and whole grains
    • exercising regularly and maintaining a lean weight
    • avoiding the harmful rays of the sun, using sunscreen, and wearing clothing that protects the skin
    • talking with a doctor about the possible benefits of drugs proven to reduce the risk of certain cancers
    Although many risk factors can be avoided, some, such as inherited conditions, are unavoidable. Still, it is helpful to be aware of them. It is also important to keep in mind that not everyone with a particular risk factor for cancer actually gets the disease; in fact, most do not. People who have an increased likelihood of developing cancer can help protect themselves by avoiding risk factors (see Question 2) whenever possible and by getting regular checkups so that, if cancer develops, it is likely to be found and treated early. Treatment is often more effective when cancer is detected early. Screening exams, such as sigmoidoscopy or the fecal occult blood testmammography, and the Pap test, can detect precancerous conditions (which can be treated before they turn into cancer) and early-stage cancer.
    The NCI is conducting many cancer prevention studies to explore ways to reduce the risk of developing cancer. These studies are evaluating dietary supplements, chemopreventive agents,nutrition, personal behaviors, and other factors that may prevent cancer. More information about cancer prevention trials is available in the following NCI resources:
    See Question 6 for additional information about clinical trials related to the prevention, screening, diagnosis, and treatment of cancer.
  4. What are some of the common signs and symptoms of cancer?
    Cancer can cause a variety of symptoms. Possible signs of cancer include the following:
    • new thickening or lump in the breast or any other part of the body
    • new mole or an obvious change in the appearance of an existing wart or mole
    • a sore that does not heal
    • nagging cough or hoarseness
    • changes in bowel or bladder habits
    • persistent indigestion or difficulty swallowing
    • unexplained changes in weight
    • unusual bleeding or discharge
    When these or other symptoms occur, they are not always caused by cancer. They can be caused by infections, benign tumors, or other problems. It is important to see a doctor about any of these symptoms or about other physical changes. Only a doctor can make a diagnosis. A person with these or other symptoms should not wait to feel pain because early cancer usually does not cause pain.
    If symptoms occur, the doctor may perform a physical examination, order blood work and other tests, and/or recommend a biopsy. In most cases, a biopsy is the only way to know for certain whether cancer is present. During a biopsy, the doctor removes a sample of tissue from the abnormal area. A pathologist studies the tissue under a microscope to identify cancer cells.
  5. How is cancer treated?
    Cancer treatment can include surgery, radiation therapy, chemotherapy, hormone therapy, and biological therapy. The doctor may use one method or a combination of methods, depending on the type and location of the cancer, whether the disease has spread, the patient's age and general health, and other factors. Because treatment for cancer can also damage healthy cells and tissues, it often causes side effects. Some patients may worry that the side effects of treatment are worse than the disease. However, patients and doctors generally discuss the treatment options, weighing the likely benefits of killing cancer cells and the risks of possible side effects. Doctors can suggest ways to reduce or eliminate problems that may occur during and after treatment.
    Surgery is an operation to remove cancer. The side effects of surgery depend on many factors, including the size and location of the tumor, the type of operation, and the patient's general health. Patients have some pain after surgery, but this pain can be controlled with medicine. It is also common for patients to feel tired or weak for a while after surgery.
    Patients may worry that having a biopsy or other type of surgery for cancer will spread the disease. This is a very rare occurrence because surgeons take special precautions to prevent cancer from spreading during surgery. Also, exposing cancer to air during surgery does not cause the disease to spread.
    Radiation therapy (also called radiotherapy) uses high-energy rays to kill cancer cells in a targeted area. Radiation can be given externally by a machine that aims radiation at the tumor area. It can also be given internally; needles, seeds, wires, or catheters containing a radioactivesubstance are placed directly in or near the tumor. Radiation treatments are painless. The side effects are usually temporary, and most can be treated or controlled. Patients are likely to feel very tired, especially in the later weeks of treatment. Radiation therapy may also cause a decrease in the number of white blood cells, which help protect the body against infection. With external radiation, it is also common to have temporary hair loss in the treated area and for the skin to become red, dry, tender, and itchy.
    There is no risk of radiation exposure from coming in contact with a patient undergoing external radiation therapy. External radiation does not cause the body to become radioactive. With internal radiation (also called implant radiation), a patient may need to stay in the hospital, away from other people, while the radiation level is highest. Implants may be permanent or temporary. The amount of radiation in a permanent implant goes down to a safe level before the person leaves the hospital. With a temporary implant, there is no radioactivity left in the body after the implant is removed.
    Chemotherapy is the use of drugs that kill cancer cells throughout the body. Healthy cells can also be harmed, especially those that divide quickly. The doctor may use one drug or a combination of drugs. The side effects of chemotherapy depend mainly on the drug(s) and thedose(s) the patient receives. Hair loss is a common side effect of chemotherapy; however, not all anticancer drugs cause loss of hair. Anticancer drugs may also cause temporary fatigue, poor appetite, nausea and vomiting, diarrhea, and mouth and lip sores. Drugs that prevent or reduce nausea and vomiting can help with some of these side effects. Normal cells usually recover when chemotherapy is over, so most side effects gradually go away after treatment ends.
    Hormone therapy is used to treat certain cancers that depend on hormones for their growth. It works by keeping cancer cells from getting or using the hormones they need to grow. This treatment may include the use of drugs that stop the production of certain hormones or that change the way hormones work. Another type of hormone therapy is surgery to remove organs that make hormones. For example, the ovaries may be removed to treat breast cancer, or the testicles may be removed to treat prostate cancer.
    Hormone therapy can cause a number of side effects. Patients may feel tired, or have fluidretention, weight gain, hot flashes, nausea and vomiting, changes in appetite, and, in some cases, blood clots. Hormone therapy may also cause bone loss in premenopausal women. Depending on the type of hormone therapy used, these side effects may be temporary, long lasting, or permanent.
    Biological therapy uses the body's immune system, directly or indirectly, to fight disease and to lessen some of the side effects of cancer treatment. Monoclonal antibodies, interferoninterleukin-2, and colony-stimulating factors are some types of biological therapy.
    The side effects caused by biological therapy vary with the specific treatment. In general, these treatments tend to cause flu-like symptoms, such as chills, fever, muscle aches, weakness, loss of appetite, nausea, vomiting, and diarrhea. Patients also may bleed or bruise easily, get a skin rash, or have swelling. These problems can be severe, but they go away after the treatment stops.
  6. Are clinical trials (research studies) available? Where can people get more information about clinical trials?
    Yes. Clinical trials are an important treatment option for many cancer patients. To develop new, more effective treatments, and better ways to use current treatments, the NCI is sponsoring clinical trials in many hospitals and cancer centers around the country. Clinical trials are a critical step in the development of new methods of treatment. Before any new treatment can be recommended for general use, doctors conduct clinical trials to find out whether the treatment is safe for patients and effective against the disease.
    People interested in taking part in a clinical trial should talk with their doctor. Information about clinical trials is available from the NCI's Cancer Information Service (CIS) (see below) at 1–800–4–CANCER and in the NCI booklet Taking Part in Cancer Treatment Research Studies, which is available at http://www.cancer.gov/publications on the Internet. This booklet describes how research studies are carried out and explains their possible benefits and risks. Further information about clinical trials is available at http://www.cancer.gov/clinicaltrials on the NCI's Web site. The Web site offers detailed information about specific ongoing treatment trials as well as trials focused on prevention, screening, and diagnosis by linking to PDQ®, the NCI's comprehensive cancer information database. The CIS also provides information from PDQ.
  7. Does cancer always cause pain?
    Having cancer does not always mean having pain. Whether a patient has pain may depend on the type of cancer, the extent of the disease, and the patient's tolerance for pain. Most pain occurs when the cancer grows and presses against bones, organs, or nerves. Pain may also be a side effect of treatment. However, pain can generally be relieved or reduced with prescriptionmedicines or over-the-counter drugs recommended by the doctor. Other ways to reduce pain, such as relaxation exercises, may also be useful. Pain should not be accepted as an unavoidable part of having cancer. It is important for patients to talk about pain so steps can be taken to help relieve it. The fear of addiction or “losing control” should not stop patients from taking pain medication. Patients who take medications for cancer pain, as prescribed by their doctor, rarely become addicted to them. In addition, changing the dose or type of medication can usually help if the patient has troublesome side effects.